• 10 Posts
  • 605 Comments
Joined 3 years ago
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Cake day: July 4th, 2023

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  • It’s slightly more lipophilic, not heavily so. The main draw of meth from a pharmacodynamic perspective is that it slows enzymatic degradation (you’re high longer). On a mg for mg basis dextroamphetamine is actually stronger than meth.

    Tooth decay is caused by dry mouth and poor hygiene. The added methyl group doesn’t affect this aspect.



  • You’re not comprehending what you’re reading. In that sentence, when it says it modulates the pro-inflammatory and anti-inflammatory response, it’s saying it affects both, It’s not saying that the nervous system itself is pro-inflammatory.

    Together, these results uncovered two lines of signalling from the vagal ganglia to the brain. One line (TRPA1) carries anti-inflammatory signals and acts on cNST neurons to enhance the anti-inflammatory response (for example, by positive feedback onto immune cells releasing anti-inflammatory cytokines) and helps to suppress the pro-inflammatory state. The other (CALCA neurons) responds to pro-inflammatory signals and helps to tune down the pro-inflammatory response (for example, by negative feedback onto immune cells releasing pro-inflammatory cytokines).

    To “tune down a pro-inflammatory response” and “enhance an anti-inflammatory response” are both anti-inflammatory effects achieved through modulating both anti- and pro- inflammatory responses. Enhance one, diminish another.


  • We demonstrate that pro-inflammatory and anti-inflammatory cytokines communicate with distinct populations of vagal neurons to inform the brain of an emerging inflammatory response.

    Where do you think those cytokines that are influencing the nervous system come from? White blood cells. That’s where it all starts, not the nervous system. You’re putting the cart before the horse.

    Chemogenetic activation of the cNST neurons during an immune response suppresses inflammation.

    The study you linked demonstrates the brain suppresses inflammation/fever, not promotes it.



  • So profits is a main driver

    This is exactly what I’m getting at. If these groups of humans were placed in the same scenarios that Europeans or other westerners were placed in, would they not be susceptible to the same greed that motivated them?

    I do not deny that many native societies appear to live in more harmony with the environment than your average westerner. There is certainly a lot to learn there, and I believe we would do better if we emulated some of those characteristics. However, I think that we’re all susceptible to the same flaws, as we are all human.

    Ultimately what I’m saying is I don’t think that natives have some superpower where they have figured out how to escape the flaws that have plagued humanity for thousands of years.



  • This reeks of the “noble savage” stereotype. I would be willing to bet 80% of biodiversity being in native lands has more to do with how brutally they’ve been repressed than how “in tune” with the environment they are.

    They’re people too, and I see little reason to believe they wouldn’t fall to the same human flaws as the rest of us if given the chance.